2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-12724AR
    Guanabenz hydrochloride (Standard) 23113-43-1 98%
    Guanabenz (hydrochloride) (Standard) is the analytical standard of Guanabenz (hydrochloride). This product is intended for research and analytical applications. Guanabenz hydrochloride is an orally active α-2-adrenoceptor agonist. Guanabenz hydrochloride has antihypertensive effect and antiparasitic activity. Guanabenz hydrochloride interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz hydrochloride also is used for the research of high blood pressure.
    Guanabenz hydrochloride (Standard)
  • HY-12767S2
    Carvedilol metabolite 4-Hydroxyphenyl Carvedilol-13C6 98%
    Carvedilol metabolite 4-Hydroxyphenyl Carvedilol-13C6 (4-Hydroxycarvedilol Carvedilol-13C6) is 13C labeled Carvedilol metabolite 4-Hydroxyphenyl Carvedilol.
    Carvedilol metabolite 4-Hydroxyphenyl Carvedilol-13C6
  • HY-128510A
    Colterol hydrochloride 52872-37-4 98%
    Colterol hydrochloride is the hydrochloride salt form of Colterol (HY-128510). Colterol hydrochloride is the agonist for adrenergic receptor, and exhibits good affinity to β1-adrenoreceptor (heart) and β2-adrenoreceptor (lung) with IC50 of 645 nM and 147 nM. Colterol hydrochloride exhibits potential as a bronchodilator.
    Colterol hydrochloride
  • HY-128932R
    Cefminox sodium (Standard) 75498-96-3 98%
    Cefminox (sodium) (MT-141) (Standard) is the analytical standard of Cefminox (sodium). This product is intended for research and analytical applications. Cefminox sodium is a semisynthetic cephamycin, which exhibits antibacterial activity. Cefminox sodium is a broad-spectrum, bactericidal cephalosporin antibiotic. Cefminox sodium also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ. Cefminox sodium upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium also prevents pulmonary arterial hypertension in rat model.
    Cefminox sodium (Standard)
  • HY-130304S
    8-Isoprostaglandin E2-d4 98%
    8-Isoprostaglandin E2-d4 (iPE2-III-d4) is deuterium labeled 8-Isoprostaglandin E2. 8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A2 (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway.
    8-Isoprostaglandin E2-d4
  • HY-131118R
    Desmethyl Ketoprofen (Standard) 22071-22-3
    Desmethyl Ketoprofen (Standard) is the analytical standard of Desmethyl Ketoprofen. This product is intended for research and analytical applications.
    Desmethyl Ketoprofen (Standard)
  • HY-131276R
    Olmesartan lactone impurity (Standard) 849206-43-5
    Olmesartan lactone impurity (Standard) is the analytical standard of Olmesartan lactone impurity. This product is intended for research and analytical applications. Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study.
    Olmesartan lactone impurity (Standard)
  • HY-133114R
    Ezetimibe ketone (Standard) 191330-56-0 98%
    Ezetimibe ketone (Standard) is the analytical standard of Ezetimibe ketone (HY-133114). This product is intended for research and analytical applications. Ezetimibe ketone is an orall active Nrf2 activator and ROS inhibitor. Ezetimibe ketone attenuates H2O2-induced reactive oxygen species production and reduces H2O2-induced apoptosis in renal tubular epithelial cells. Ezetimibe ketone suppresses renal tubular injury and inflammation.
    Ezetimibe ketone (Standard)
  • HY-133885A
    R-(-)-7-Desmethyl-8-nitro blebbistatin 1217619-62-9 98%
    R-(-)-7-Desmethyl-8-nitro blebbistatin is an analog of (-)-Blebbistatin (HY-13441). (-)-Blebbistatin is a selective non-muscle myosin II inhibitor.
    R-(-)-7-Desmethyl-8-nitro blebbistatin
  • HY-13458S2
    Droxidopa-13C6 1261397-37-8 98%
    Droxidopa-13C6 (L-DOPS-13C6) is 13C labeled Droxidopa. Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder).
    Droxidopa-13C6
  • HY-13463BR
    Avatrombopag hydrochloride (Standard) 570403-17-7
    Avatrombopag (hydrochloride) (Standard) is the analytical standard of Avatrombopag (hydrochloride). This product is intended for research and analytical applications. Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A.
    Avatrombopag hydrochloride (Standard)
  • HY-135121R
    Ethacizine hydrochloride (Standard) 57530-40-2
    Ethacizine (hydrochloride) (Standard) is the analytical standard of Ethacizine (hydrochloride). This product is intended for research and analytical applications. Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than Flecainide. Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction.
    Ethacizine hydrochloride (Standard)
  • HY-135384R
    tert-Buthyl Pitavastatin (Standard) 586966-54-3 98%
    Flavone (Standard) is the analytical standard of Flavone. This product is intended for research and analytical applications. Flavone is an endogenous metabolite.
    tert-Buthyl Pitavastatin (Standard)
  • HY-135514R
    Lys-Phe (Standard) 6235-35-4 98%
    Lys-Phe (Standard) is the analytical standard of Lys-Phe. This product is intended for research and analytical applications. Lys-Phe is a dipeptide that inhibits both cell sickling and the gelation of solutions of sickle-cell haemoglobin.
    Lys-Phe (Standard)
  • HY-135517A
    (2R)-RXP470.1 98.70%
    (2R)-RXP470.1 ((2R)-RXP-470) is the (2R)-isomer of RXP470.1 (HY-135517). RXP470.1 (RXP-470) is a potent, selective MMP-12 inhibitor with a Ki of 0.2 nM against human MMP-12.
    (2R)-RXP470.1
  • HY-135774R
    6-Hydroxybenzbromarone (Standard) 152831-00-0
    1-(Carboxymethyl)cyclohexanecarboxylic acid (Standard) is the analytical standard of 1-(Carboxymethyl)cyclohexanecarboxylic acid. This product is intended for research and analytical applications. 1-(Carboxymethyl)cyclohexanecarboxylic acid (1-Carboxycyclohexaneacetic acid; Gabapentin Impurity E) is a potential impurity in commercial preparations of the antiepileptic agent Gabapentin (HY-A0057). It is also used as a precursor for the synthesis of a serotonin (5-HT) receptor subtype 5-HT2A antagonist.
    6-Hydroxybenzbromarone (Standard)
  • HY-13599S1
    Cladribine-13C5,15N2 98%
    Cladribine-13C5,15N2 (2-Chloro-2′-deoxyadenosine-13C5,15N2) is 13C and 15N labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis.
    Cladribine-13C5,15N2
  • HY-13599S2
    Cladribine-15N 1360874-38-9 98%
    Cladribine-15N (2-Chloro-2′-deoxyadenosine-15N) is 15N labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis.
    Cladribine-15N
  • HY-137378A
    8-Br-PET-cGMP 144510-04-3 98%
    8-Br-PET-cGMP is an agonist of cGMP-dependent protein kinase type I (cGKI). 8-Br-PET-cGMP promotes the dimerization of cGKI and activates its catalytic activity by binding to the regulatory domain of cGKI. 8-Br-PET-cGMP can be used to study the role of cGMP signaling pathways in cell growth, vasodilation, and smooth muscle cell function.
    8-Br-PET-cGMP
  • HY-137431S
    Asundexian-d3 2975248-62-3
    Asundexian-d3 (BAY-2433334-d3) is the deuterium labeled Asundexian (HY-137431). Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM.
    Asundexian-d3
Cat. No. Product Name / Synonyms Application Reactivity